ea0015p191 | Endocrine tumours and neoplasia | SFEBES2008
Lemos Manuel
, Harding Brian
, Reed Anita
, Walls Gerard
, Tyler Damian
, Bazan-Peregrino Miriam
, Ansorge Olaf
, Clarke Kieran
, Seymour Len
, Thakker Rajesh
The mouse knockout model for multiple endocrine neoplasia type 1 (MEN1) closely resembles the phenotype of the human disorder, with frequent development of tumours of the parathyroids, pancreas and pituitary. These tumours have loss of heterozygosity (LOH) of the Men1 locus and lack expression of the encoded protein (menin).The aim of this study was to investigate the feasibility of detecting pituitary tumours in heterozygous (Men1+/−...